Autophagy is induced by anti-neutrophil cytoplasmic Abs and promotes neutrophil extracellular traps formation

Extracellular Traps Promotes Formation of Neutrophil Leukotoxin GH Staphylococcus aureus

Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies

Neutrophil extracellular traps (NETs) are chromatin filaments decorated with enzymes from neutrophil cytoplasmic granules. Anti-neutrophil cytoplasmic antibodies (ANCAs) bind to enzymes from neutrophil cytoplasmic granules and are biomarkers for the diagnosis of systemic vasculitides. ANCA diagnostics are based on indirect immunofluorescence (IIF) of ethanol-fixed neutrophils. IIF shows a cytop...

Neutrophil extracellular traps (NETs) - formation and implications.

Neutrophils are cells of the immune system which freely circulate in blood vessels and are recruited to the inflammation sites when the human organism responds to microbial infections. One of the mechanisms of neutrophil action is the formation of neutrophil extracellular traps (NETs) The process of NET generation, called netosis, is a specific type of cell death, different from necrosis and ap...

Neutrophil extracellular traps

Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.

Neutrophil extracellular traps

Coming soon to a doctor’s surgery near you? Hopes placed on the sequencing of ‘the’ human genome and the subsequent identification of many single-nucleotide polymorphisms (SNPs) have turned out to be misguided, as the causes of common diseases like cancer and heart disease have proven too complex to be addressed with simple SNP searches. Also, large-scale genomic differences like copy number va...